I dont think there is reason for paranoia over this - just perhaps a little extra care.. If one makes the tone as 'rough' (highest harmonic content) as possible, this should make the sound 'louder', reduce the risk of high amplitude overload, and reduce the neurological effects of long exposure to sine waves (which can cause fatigue and further temporary reduction in the level of the sound heard).. Alternatively, lots of fast vibrato may help to make the sound appear louder.
"Maybe it's a bit like when you look out the window when it's raining and then when you look away you get little streams in your vision?"
Sorry - I dont know that one! Perhaps because I wear glasses or dont look as well as I listen... But I think the visual neurological signals tend to be far more 'processed' than audio signals.. The eye/brain has difficulty with any stimuli occurring more than 30Hz - and much of what we 'see' is probably a complex composite and not 'reality' .. Audio processing is far faster - exact mechanisms not well understood - but we can hear distortion on a 5kHz signal easily, which means we must be able to update a 'snapshot' of audio at least 10,000 times a second - Altenatively, the brain has a real-time spectrum analyser capable of this rapid processing... As far as I know, audio processing is the fastest activity undertaken by the brain.